By B.-E. Wiholm (auth.), Dr. Michael Kurowski (eds.)
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Extra resources for Adverse Reactions to Non-Steroidal Anti-Inflammatory Drugs: Clinical Pharmacoepidemiology
Anonymous, Syntex on Feldene/Naprosyn. Scrip no 1090/91, 18 (1986) . 45 . Anonymous, Piroxicam vs. naproxen assessed. Scrip no. 1076,26 (1986) . 46 . G. and Sakshaug, S. ), Drug use in Norway. Norwegian Medicinal Depot , Oslo 1990. 47 . Nordic Statistics on Medicines 1987-1989 (NLN publication no. 30). Nordic Council on Medicines, Uppsala 1990. 48 . , Drugs used in rheumatic diseases. In: Sakshaug, S. et. ), Drug utilization in Norway during the 1970s: increases, inequalities, innovations. Norwegian Medicinal Depot,Oslo 1983, pp.
109: 359 (1988). 24. , Nonsteroidal anti-inflammatory drugs : retrospective study of 272 bleeding or perforated peptic ulcers. Postgrad. Med . J. 65: 892 (1989). 25 . S. , Use of anti-inflammatory drugs by patients admitted with smalI and large bowel perforation and haemorrhage. Br. Med. J. 290: 347 (1985). 26.
Recent examples of discontinued non-steroidal anti-inflammatory drugs (NSAIDs) include phenylbutazone , benoxaprofen , and zomepirac . DUS are challenged to justify a nearly worldwide ban on these drugs. Phenylbutazone and oxyphenebutazone were stigmatized as being the most toxic NSAIDs. This has been confirmed vis-ä-vis agranulocytosis and aplastic anemia ; however, indomethacin and some other NSAIDs seem to present similar risks . These risks are generally quite low when the drugs are used in an appropriate manner.