By Jan Agosti
Illustrates advanced interactions inside mucosa and the airway wall to big organic pathways and convey new therapeutics within the administration of allergic disorders.
summary: Illustrates complicated interactions inside of mucosa and the airway wall to special organic pathways and bring new therapeutics within the administration of allergic problems
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Extra info for Biotherapeutic Approaches to Asthma Biotherapeutic Approaches to Asthma
16. Rosenstreich DL, Eggleston P, Kattan M, Baker D, Slavin RG, Gergen P, Mitchell H, McNiff-Mortimer K, Lynn H, Ownby D, Malveaux F. The role of cockroach allergy and exposure to cockroach allergen in causing morbidity among inner-city children with asthma. [see comments]. N Engl J Med 1997; 336(19):1356–1363. 17. Platts-Mills TA, Tovey ER, Mitchell EB, Moszoro H, Nock P, Wilkins SR. Reduction of bronchial hyperreactivity during prolonged allergen avoidance. Lancet 1982; 2(8300):675–678. 18. Peat JK, Tovey E, Toelle BG, Haby MM, Gray EJ, Mahmic A, Woolcock AJ.
60. 61. 62. Erwin and Platts-Mills exposure to skin test sensitivity in inner-city children with asthma. J Allergy Clin Immunol 1998; 102:563–570. Sporik R, Squillace SP, Ingram JM, Rakes G, Honsinger RW, Platts-Mills TAE. Mite, cat, and cockroach exposure, allergen sensitization, and asthma in children: A case-control study of three schools. Thorax 1999; 54:675–680. Carter MC, Perzanowski MS, Raymond A, Platts-Mills TAE. Home intervention in the treatment of asthma among inner-city children. J Allergy Clin Immunol 2001; 108:732–737.
For other allergens there are still extensive problems with the regimes recommended for avoidance. In particular, there is evidence that a large part of the problem for catallergic patients relates to allergen exposure in public places such as school or in homes without a cat. Primary avoidance studies have shown beneﬁt, and several are ongoing. However, it appears that the results may be confounded by the effects of passive exposure to cat allergen. Interestingly, effective mite avoidance measures may play an indirect role in decreasing exposure to passively transferred cat allergen.