By Beat Thürlimann
This e-book presents a clinically orientated review at the patho-physiological history and using bisphosphonates in oncology. The scientific improvement of pamidronate to regard tumor-induced hypercalcemia and malignant osteolytic bone sickness is tested, in addition to the result of pivotal reports. New very important findings on easy methods to top use pamidronate in sure symptoms are given and installed viewpoint. the writer discusses sufferer administration directions in addition to pharmaco-economic points very important for the readers.
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Additional info for Bisphosphonates in Clinical Oncology: The Development of Pamidronate
Early studies were done in the Rheumatology Department of the University of Basel (Prof. Miiller) and in the Department of Internal Medicine of the University Hospital in Lausanne (Prof. Burckardt). Most of the pharmacokinetic data which finally served for registration purposes with the state authorities were obtained in the United Kingdom. Clinically, pamidronate has been used in Paget's disease and tumor-induced hypercalcemia. Its application in some other rare conditions such as bone lesions in Gaucher's disease (Samuel et al.
Henkel intended to use· these compounds, which were then still called diphosphonates, not only as an additive in washing powder but also in cosmetics and other products such as toothpaste. The state authorities then required a "minipharmacology" with special regard to toxicology. One of the members of the board of directors of Henkel at that time was also on the executive board of the Ciba company. This was the Ciba's first contact with bisphosphonates. At that time, Ciba still had no official interest in the bisphosphonates, but Prof.
The effect of estrogens may be mediated by modulation of factors released by osteoblasts, which influence osteoclast activity in a paracrine fashion. The mechanism by which estrogens inhibit bone resorption remains unknown so far. Tamoxifen, a non-steroidal antiestrogen is established as the endocrine therapy of choice, in breast cancer both in advanced disease and in the adjuvant setting. The differential actions of tamoxifen occur by selective estrogen-receptor modulation at different target sites to produce estrogenic or antiestrogenic effect.