By Liv Storstein (auth.), Professor Dr. med. Kurt Greeff (eds.)
The pharmacokinetics of digitalis glycosides were the topic of in depth re view (IISALO, 1977; ARONSON, 1980; PERRIER et ai., 1977). examine on glycoside kinetics has stepped forward at a swift velocity, requiring carrying on with reevaluation of the kingdom of our knowing of this challenge. the current article makes a speciality of the influence of affliction states (renal, gastrointestinal, thyroid, and cardiac) at the absorption, distribution, and clearance of a couple of digitalis glycosides. proof is significantly reviewed, and interpreted with admire to attainable scientific implications. A. Renal Insufficiency I. Strophanthin Strophanthin disposition in renal failure has been evaluated in just experiences. KRAMER et ai. (1970) decided an removal half-life of 14 h in normals as com pared to 60 h in anuric sufferers. comparable effects have been mentioned by way of BRASS and Pm LIPPS (1970) utilizing tritiated strophanthin. they discovered a half-life price of 18 h in fit participants in comparison to sixty eight h in anuric sufferers. The findings in actual fact in dicate that the removing half-life of strophanthin is lengthy in renal failure.
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Additional info for Cardiac Glycosides: Part II: Pharmacokinetics and Clinical Pharmacology
1. BioI. Chern. : Fate of orally administered 3H-digitoxin in man with special reference to absorption. : The efficacy of lymph drainage in the elimination of orally administered digitoxin and digoxin. : Digitalis intoxication. A prospective clinical study with serum level correlations. N. Engl. J. Med. : Organverteilung verschiedener Herzglykoside. In: Digitalistherapie, Beitriige zur Pharmakologie. Jahrmiirker, H. ), pp. 25-34. : Clinical application of serum digitoxin levels. A simplified plasma determination.
1975). In view of these possible factors the extreme variability in the glycoside concentration of myocardium is more understandable. However, there does exist a complex relationship between the glycoside concentration in the myocardium and the concentration in serum such that estimations of serum glycoside concentration in regard to clinical observations are sensible and useful guides in the control of digitalis therapy. Considerable differences in the distribution of digoxin and f1-methyldigoxin have been found in the central nervous system.
The effect of colestipol on digitoxin plasma levels. Arzneim. Forsch. , Unruh, E. : Dihydrodigitoxin, a metabolite of digitoxin in humans. In: Cardiac glycosides, International Boehringer Mannheim Symposia. J. ), part I, pp. 74--84. : The excretory products oflanatoside C and digitoxin in the rat. 1. Pharmacol. Exp. Ther. : Interruption of the enterohepatic circulation of digitoxin by cholestyramine. II. Effect on metabolic disposition of tritium-labeled digitoxin and cardiac systolic intervals in man.