Download Cellular and Molecular Biology of Myelination by Monique Dubois-Dalcq, Regina Armstrong, Bryn Watkins, PDF

By Monique Dubois-Dalcq, Regina Armstrong, Bryn Watkins, Randall McKinnon (auth.), Gunnar Jeserich, Hans H. Althaus, Thomas V. Waehneldt (eds.)

Specialists within the box of mobile and molecular biology of myelination current their most recent effects. a variety of ideas have been used akin to tissue tradition, transplantation, transfection, immunocytochemistry and techniques to check the phylogenetic features of myelination in addition to molec- ular biology. touching on glial cells: hormones and moment messengers play a tremendous function within the rules of the phenotype and the expression of myelin parts on the transcriptional point; those findings also are a part of specific relevance for remyelination. pertaining to myelin: compositional reports printed more and more minor parts to be of the most important value for mobile adhesion strategies; from a phylogenetic perspective vertebrate myelin has existed for four hundred million years with vital changes in its compositon. This e-book bargains a very good selection of the newest effects offered by way of the world over reknowned scientists.

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This model includes both several developmental stages as well as functional subpopulations of adult oligo dendrocytes. , MBP+ make up approximately 95 % of the total number of cells in both systems. The presence of Tf mRNA, together with Tf in the cytoplasm of oligodendrocytes suggests active synthesis ofTfby these cells. However, in order to prove it, we have studied the synthesis and secretion of Tf by oligodendrocytes in vitro. Pure cultures of oligodendrocytes were prepared as described by McCarthy and de Vellis (1980).

OfBiomed. , UCLA Sch. ofMed. University of California, Los Angeles 760 Westwood Plaza, Rm. 68-225 NPI Los Angeles, CA 90024-1759, USA Oligodendrocytes represent one of the three major cell types in the central nervous system (CNS). Their main function has traditionally been recognized as the production of the myelin components which are added to the plasma membrane of olidogdendrocytes as they coil their processes around axons to form the elaborate multilayered myelin sheath. History and Description ofthe Oligodendrocyte The first description of this cell was reported by Robertson in 1899.

Therefore, we consider that the colocalization ofGC and Tf confirms that in our cultures, Tfpositive cells are oligodendrocytes. To verify the relevance of these findings in tissue culture, we decided to study the expression of Tf and MBP in vivo. , 1989). The results of these studies are represented in Fig. 2a. 100 80 a / 60 40 0 ~ 20 oL-~~~~--~~~/====1~ 100 10 20 30 days 1 yeor b .!!!. , 40 a. 20 0; ~ 10 20 30 days Fig. 2. Quantification of Tf+ and MBP+ cells from (a) freshly dissociated cells from normal rat brains (b) freshly dissociated cells from md rat brains and (c) primary glial cultures established from normal newborn rat brains.

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