Download Cholesterol: Its Functions and Metabolism in Biology and by Simon M. Jackson, Johan Ericsson, Peter A. Edwards (auth.), PDF

By Simon M. Jackson, Johan Ericsson, Peter A. Edwards (auth.), Robert Bittman (eds.)

Experts examine the biochemical and biomedical facets of ldl cholesterol, addressing its metabolism in basic and affliction states. They speak about a vast diversity of themes, together with key steps within the ldl cholesterol biosynthetic pathway, and the position of ldl cholesterol in melanoma, atherosclerosis, and illnesses of the anxious approach. The book's complete assurance additionally contains the pathological outcomes and capability remedies for varied ailment states, and the advance of recent anti-atherogenic drugs.

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Xiu, R. , 1994, Atherosclerosis and sterol 27-hydroxylase: Evidence for a role of this enzyme in elimination of cholesterol from human macrophages, Proc. Natl. Acad. Sci. USA 91:8592-8596. Bonifacino, J. , 1991, Cur~ Opin. Cell BioI. 3:592-600. Bradfute, D. , and Simoni, R. , 1994, Non-sterol compounds that regulate cholesterogenesis, J. BioI. Chern. 269:6645-6650. Brown, M. , and Goldstein, J. , 1993, Mad bet for rab, Nature 366: 14-15. Byskov, A. , Andersen, C. , Nordholm, L. , Andersen, J.

1992). 9. CONCLUSION As discussed in this chapter, many molecules of the cholesterol biosynthetic pathway, including isoprenoids, sterols, and further metabolites of cholesterol, can function as signaling molecules. These molecules regulate diverse cell functions, ranging from meiosis to apoptosis. In light of these observations, we should expect to find a multifactorial and intricate mode of regulation of this important metabolic pathway. A major challenge is to define these mechanisms of regulation.

1986, Anti-Mullerian hormone, Physiol. Rev. 66: 1038-1090. Kandutsch, A. , Chen, H. , 1978, Biological activity of some oxygenated sterols, Science 201:498-501. Keller, G. , 1986, 3-Hydroxy-3-methylglutaryl coenzyme A reductase localization in rat liver peroxisomes and microsomes of control and cholestyramine-treated animals: quantitative biochemical and immunoelectron microscopical analysis, 1. Cell BioI. 103: 875-886. 20 Simon M. Jackson et al. , 1990, Protein degradation in the endoplasmic reticulum, Cell 62: 611-614.

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