Download Clinical Applications of Cardiovascular Drugs by Leonard S. Dreifus, Joel Morganroth (auth.), Leonard S. PDF

By Leonard S. Dreifus, Joel Morganroth (auth.), Leonard S. Dreifus, Albert N. Brest (eds.)

During the earlier decade huge, immense development has been made within the improvement of latest cardiovascular medicinal drugs and in our realizing of the scientific pharma­ cology and the pharmacokinetics of previous medicines. moreover, more recent functions of older brokers have emerged. for instance, vasodilators akin to nitroglycerin at the moment are being hired within the remedy of congestive center failure, and anti­ hypertensives corresponding to bretylium are utilized in the administration of ventricular arrhythmias. person chapters during this booklet specialise in (1) the scientific pharmacology and pharmacokinetics of the person medications, and (2) the medical functions of those medications, with awareness additionally to serum concentrations, pathophysiology, and drug interactions the place acceptable. The members to this article have worked to supply the reader with a significant, functional replace at the medical makes use of and usability of cardioactive medications. we're deeply thankful to every of them for his or her beneficiant participation during this recreation. LEONARD S. DREIFUS, M.D. ALBERT N. BREST, M.D. 1. ANTIARRHYTHMIC brokers LEONARD S. DREIFUS and JOEL MORGANROTH preferably, the administration of cardiac arrhythmias has to be predicated on (1) entire elucidation of the genesis of a few of the rhythm disturbances, and (2) a whole knowing of the pharmacologic motion of person antiarrhythmic brokers. simply with this certain info does it turn into attainable to manage a selected agent or brokers particularly potent opposed to a given arrhythmia.

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20. Wittig J. Harrison LA, Wallace AG: Electrophysiological effects oflidocaine on distal Purkinje fibers of canine heart. Am Heart J 86: 69, 1973. 21. Myerburg P J. Steward JW, Hoffman BF: Electrophysiological properties of the canine peripheral A V conducting system. Circ Res 20: 361, 1970. 22. Wit AL, Rosen MR, Hoffman BF: Electrophysiology and pharmacology of cardiac arrhythmias. II. Relationship of normal and abnormal electrical activity of cardiac fibers to the genesis of arrhythmias. A. Automaticity.

Cannon F, Sjostrand T: The occurrence of a positive after-potential in the ECG in different physiological and pathological conditions. Acta Med Scand 146: 191, 1953. ANTIARRHYTHMIC AGENTS 45 164.

75 mg/kg/minute. produced a small but statistically significant increase in the pulmonary and systemic vascular resistance and in aortic and pulmonary arterial pressures in twelve patients with compensated left ventricular dysfunction. Left and right ventricular end-diastolic pressures rose slightly but there was no change in left ventricular dp/dt, heart rate or cardiac index (123). 3. Antiarrhythmic and electrophysiologic effects In isolated Purkinje fibers, tocainide decreases the action potential duration and maximal rate of rise of phase 0 (Vmax).

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