By Martin Rohrer (auth.), Tim Leiner, Mathias Goyen, Martin Rohrer, Stefan Schönberg (eds.)
Clinical Blood Pool MR Imaging
»This first-class treatise on Vasovist® created via a staff of outstanding school who're pioneers in
MR Angiography covers the fundamental thoughts, protection, efficacy, snapshot processing and pharmaco-economic
details to effectively enforce a brand new point of MRA snapshot caliber with this new distinction agent.«
Martin Prince, Cornell collage, New York
»The editors and authors have made groundbreaking contributions in the direction of developing MR angiography
in quite a few investigative settings, rendering it extra detailed and employing it for various indications.
The paintings offered here's based upon the huge event of the editors, in addition to the broad
range of expertise from different medical operating groups.«
Maximilian Reiser, Ludwig Maximilian college, Munich
Vasovist® (Gadofosveset), around the globe the 1st blood pool agent, has only in the near past turn into to be had for
clinical use, yet has already won large recognition as a device to enhance magnetic resonance angiography.
This publication provides the 1st in-depth advent to the fundamental physicochemical elements of the agent,
the program of Vasovist® in scientific MRA, in addition to capability medical functions past MRA and
patient management-related aspects.
The first a part of the booklet explains uncomplicated and technical homes of the agent and the differences
of Vasovist® in comparison to at the moment to be had extracellular brokers. the second one half includes detailed
chapters on defense and efficacy. within the 3rd half the point of interest is on MR angiographic applications,
and within the fourth a part of the e-book capability medical fields past MRA are explored. All scientific chapters
feature ready-to-use medical protocols and a sequence of take domestic messages that concisely summarize
the present position of blood pool imaging for every particular indication.
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Extra info for Clinical Blood Pool MR Imaging
Steady state MRA with Gadofosveset can be performed with standard T1-weighted fast gradient echo MRA sequences. Acquisition of isotropic voxels is recommended, as this allows for multi-planar reformation and viewing of the results. The larger contrast window in steady state MRA can be used to increase the signal-to-noise ratio in highresolution data sets by increasing the number of measurements and/or by deactivation of partial k-space acquisition schemes such as half Fourier imaging . The optimum flip angle for maximizing blood-to-muscle contrast-to-noise ratio is approximately 6°–8° greater than the Ernst angle .
For contrast-enhanced MRA it is important to synchronize the data acquisition sequence with injection of the contrast agent. For correct contrast timing and to ob- tain best results, it is essential that the order of the phaseencoding data acquisition scheme is known. Sampling of the central lines of k-space should coincide with arrival of the contrast agent in the target vessels, since central kspace encodes contrast information in the reconstructed MR images while the peripheral parts of k-space encode spatial resolution (⊡ Fig.
Griswold MA, Jakob PM, Heidemann RM, Nittka M, Jellus V, Wang J, Kiefer B, Haase A (2002) Generalized autocalibrating partially parallel acquisitions (GRAPPA). Magn Reson Med 47:1202–1210 11. Blaimer M, Breuer F, Mueller M, Heidemann RM, Griswold MA, Jakob PM (2004) SMASH, SENSE, PILS, GRAPPA: how to choose the optimal method. 15:223–236 12. Weiger M, Pruessmann KP, Kassner A, Roditi G, Lawton T, Reid A, Boesiger P (2000): Contrast-enhanced 3D MRA using SENSE. J Magn Reson Imaging 12:671–677 13.