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By Norbert Rietbrock, Barry G. Woodcock (auth.), Norbert Rietbrock, Barry G. Woodcock (eds.)

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Additional info for Clinical Pharmacology in the Aged / Klinische Pharmakologie im Alter: Proceedings of the 6th International Symposium on Methods in Clinical Pharmacology, Frankfurt 1985 / Vorträge des 6. Internationalen Symposiums „Methods in Clinical Pharmacology“ Frankf

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4% of elderly patients admitted to hospital suffered an ADR although the nature of the reaction was not defined. He also took no account of self purchased medication which is a large component of an elderly patient's drug therapy. 7 %. Most importantly he found that a substantial number did not recover fully after their ADR although ADR's seem to cause deaths only in severely ill patients [8]. A substantial drawback of all these reports is that they are hospital based and largely conducted from medical wards.

3. 4. 5. 6. Epidemiology of drug use Epidemiological studies on drug efficacy Single dose pharmacodynamic studies Single dose pharmacokinetic studies Multiple dose pharmacodynamic studies Multiple dose pharmacokinetic studies. B. Volunteer Studies 1. Single dose pharmacokinetic studies 2. Single dose pharmacodynamic studies C. Community-Based Studies 1. Assessment of drug effect in relation to plasma concentration. Epidemiology of Drug Use - Hypnotics The "Crooks" system of hospital drug recording was introduced in North-East Scotland in 1965 [3] and has since been widely adopted.

Soc. 30 (November supplement), S6-SlO, 1982b. Greenblatt, D. , Sellers, E. , Shader, R. : Drug disposition in old age. N. Engl. J. Med. 306, 1081-1088, 1982a. Greenblatt, D. : Clinical pharmacokinetics. N. Engl. J. Med. 293, 702-705, 964970, 1975. Greenblatt, D. , Shader, R. : Pharmacokinetics in Clinical Practice. Philadelphia, W. B. Saunders, 1985. Greenblatt, D. , Allen, M. , Harmatz, j. , Shader, R. : Diazepam disposition determinants. Clin. Pharmacol. Ther. 27,301-312,1980. Greenblatt, D. , Arendt, R.

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