Download Clinical Use of Antibodies: Tumours, infection, infarction, by D. M. Goldenberg (auth.), Richard P. Baum, Peter H. Cox, PDF

By D. M. Goldenberg (auth.), Richard P. Baum, Peter H. Cox, Gustav Hör, Gian Luigi Buraggi (eds.)

It was once at Frankfurt/Mainin 1899 that Paul Ehrlich first expounded his recognized "site-chain concept" -which defined the fundamental immunological critical of antibody-antigen interactio- at the get together of the outlet of the Institute for Experimental Therapeutics (which was once later named after him). approximately a hundred years have handed for the reason that, and on reflection it may be acknowledged that the "Ehrlich period" (first steps in immunology "Magic Bullet" thought) and the "Behring period" (detection of antibodies and serum remedy) shaped the basic foundation within the improvement of immunology. Niels ok. Jerne, the previous director of the Paul Ehrlich Institute in Frankfurt/Main bought, including Georges Kohler and Cesar Milstein, the Nobel Prize in medication 1984. those past due successors of Ehrlich and Behring first defined the hybridoma expertise (in 1975) which enabled some of the most vital and innovative technological options within the box of immunology -the creation of monoclonal antibodies. It occurs that, the time of the booklet of this publication, only a decade has handed because the first use of radiolabelled monoclonal antibodies in guy (by the Lausanne Group). Over those 10 years an important development has taken position within the box of immunoscintigraphy:A huge panel of hugely particular monoclonal antibodies opposed to tumour-associated antigens in addition to basic cellphone compounds were constructed. huge, immense growth has been made within the box of radiolabelling -from iodine-131 to technetium-99mor even positron-emittingradionuclides, e. g. iodine-124.

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Therefore, they could be of value during the follow-up of these patients. Both F( ab')2 and Fab fragments have been used instead of intact antibodies because of their different kinetics and metabolism which seem to be preferable for immunoscintigraphy(6,11). Non specific uptake of F( ab')2 fragments is less than that of intact antibody and their clearance from the circulation is more rapid. In addition, the rate of immune immunoscintigraphicstudies taking into consideration that Fab fragmented binding to tumour is less than F(ab')2 and intact antibody (6).

77: 301-311 12. Bares R. et al [1988] Validity of tomographical methods for radioimmunodetectionof gastrointestinal tumours. In: Greten H. Klapdor R. eds. New tumour markers and their monoclonal antibodies - actual clinical relevance for diagnosis and therapy of solid tumours. Thieme, 470-4 13. GranowskaM. 29: 599-607 29 14. Paganelli G. CancerSuppl. 2: 121125 15. SiccardiAG. et al [1989] Immunoscintigraph)Of adenocarcinomasby means of radiolabelled F[ab']2 fragments of anti-carcinoembryogeniamtigen monoclonal antibody.

30 27. M. [1989] Future role of radiolabelled monoclonal antibodies in oncological diagnosis and therapy. 19:332-339 28. M. 19: 262-281 29. Britton KE. et al [1989] A brief guide to the practice of radioimmunoscintigraphyand radioimmunotherapyin cancer. Markers4: 106-118 30. Cascinelli N. et al [1988] Anti-melanoma monoclonal antibody 225-28S: evaluation of toxicity in man. Tumori 4: 35-40 31. Seccamani E et al [1989] Specificity of human immunoglobulin response to murine monoclonal antibodies.

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