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Extra info for Current Topics in Developmental Biology, Vol. 11
Copyright 0 1974 Volume 7, pp. 16S183. mean slope lead to patterns very similar in shape and, with versions of the theory like Eq.
However, some systems are in a steady state, reproducing stem cells and producing differentiated cells continuously. Examples are the bone marrow system with stem cells producing granulocytes and erythrocytes, and well-fed growing and budding hydra with the interstitial cells producing nerves and nematocytes. Such steady states are particularly suitable for quantitative evaluations. A typical example for the steady-state analysis of i-cells and their products in the body column of hydra is the kinetics of incorporation of DNA precursors into nerve cells (David and Gierer, 1974).
4e), DCD predominantly in the center (Fig. 4f). If the position of head formation were determined by orientation of asymmetric cells, no difference in the results between CDC and DCD grafts would be expected since the cells have been completely disoriented upon disaggregation. The conclusion holds, even if cells align parallel to each other after the aggregates have been formed because CDC and DCD should give equal results independent of any details of such mechanisms as long as the pattern is determined by orientation only.