Download Insect Infection and Immunity: Evolution, Ecology, and by Jens Rolff, Stuart Reynolds PDF

By Jens Rolff, Stuart Reynolds

Lower than continuous assault from either microbial pathogens and multicellular parasites, bugs needs to take care of immune demanding situations each day in their lives. even if, this has no longer avoided them from changing into the main profitable crew of animals in the world. bugs own highly-developed innate immune structures which were fine-tuned by way of an hands race with pathogens spanning thousands of thousands of years of evolutionary heritage. fresh discoveries are revealing either an unforeseen measure of specificity and a sign of immunological reminiscence - the sensible hallmark of vertebrate immunity. The research of insect immune platforms has speeded up speedily lately and is now changing into an incredible interdisciplinary box. additionally, bugs are a phenomenally wealthy and various resource of antimicrobial chemical substances. a few of these are already being heavily regarded as strength healing brokers to manage microbes corresponding to MRSA. regardless of a burgeoning curiosity within the box, this is often the 1st e-book to supply a coherent synthesis and is obviously dependent round 3 greatly themed sections: mechanisms, interactions, and evolutionary ecology. This novel textual content adopts a very interdisciplinary and concept-driven technique, integrating insights from immunology, molecular biology, ecology, evolutionary biology, parasitology, and epidemiology. It beneficial properties contributions from a world staff of best specialists who additionally describe the most recent molecular immunological options.

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Additional info for Insect Infection and Immunity: Evolution, Ecology, and Mechanisms (Oxford Biology)

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Another epithelium that risks injury and infection is the genital epithelia of females following copulation. In order to prevent infection, many AMPs are expressed in this tissue. , 1998). , 2005). This induction appears to be independent of any microbial elicitors and may limit the entry of potential infectious agents just after copulation (see also Chapter 15 in this volume). 4 Interaction between the local and systemic immune response The local immune response in diverse epithelia and the systemic immune response of the fat body are independent immune mechanisms, as each can be selectively induced depending on the mode of infection.

Current Biology 12, 996–1000. , Pili-Floury, S. et al. (2003) The Drosophila immune system detects bacteria through specific peptidoglycan recognition. Nature Immunology 4, 478–484. , and Meier, P. (2006) The Drosophila IAP DIAP2 functions in innate immunity and is essential to resist gram-negative bacterial infection. Molecular and Cellular Biology 26, 7821–7831. , Bulet, P. et al. (1995) Metchnikowin, a novel immune-inducible proline-rich 32 INSECT INFECTION AND IMMUNITY peptide from Drosophila with antibacterial and antifungal properties.

EMBO Journal 21, 6330–6337. E. et al. (2006) Structural basis for preferential recognition of diaminopimelic acid-type peptidoglycan by a subset of peptidoglycan recognition proteins. Journal of Biological Chemistry 281, 8286–8295. V. (2001) The antibacterial arm of the Drosophila innate immune response requires an IkappaB kinase. Genes and Development 15, 104–110. , Vignal, C. et al. (2008) The Drosophila peptidoglycan recognition protein PGRP-LF blocks PGRP-LC and IMD/JNK pathway activation. Cell Host and Microbe 3, 293–303.

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