Download Molluscs: From Chemo-ecological Study to Biotechnological by Guido Cimino (Editor), Margherita Gavagnin (Editor) PDF

By Guido Cimino (Editor), Margherita Gavagnin (Editor)

This can be the 1st e-book on molluscs as assets for pharmaceutical medicines. Marine molluscs are very promising applicants for quite a lot of biotechnological purposes. for instance, they own analgesic medicines stronger than morphine and intensely potent anticancer brokers. foreign specialists offer insurance of the main stimulating subject matters with regards to molluscs. this information in their heritage and present reports opens the door to the longer term.

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Molluscs: From Chemo-ecological Study to Biotechnological Application (Progress in Molecular and Subcellular Biology Marine Molecular Biotechnology)

This is often the 1st booklet on molluscs as assets for pharmaceutical medicinal drugs. Marine molluscs are very promising applicants for quite a lot of biotechnological purposes. for instance, they own analgesic medicines stronger than morphine and intensely powerful anticancer brokers. foreign specialists offer assurance of the main stimulating subject matters regarding molluscs.

Additional resources for Molluscs: From Chemo-ecological Study to Biotechnological Application (Progress in Molecular and Subcellular Biology Marine Molecular Biotechnology)

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5). The aqueous 75% EtOH extract of viscera (82 kg) of P. penguin, which showed acute toxicity, was partitioned between EtOAc and H 2O. 2 M phosphate buffer), reversed-phase HPLC (Develosil 300 ODS, MeCN/H 2O/TFA), and reversed-phase HPLC (Develosil 300 C8, MeCN/H 2O/TFA) to isolate successfully pteriatoxins A (10) and B, C (11, 12 as a 1:1 mixture) as extremely toxic and minor components (Takada et al. 2001b). Since there was too little of these toxins to weigh, the weights of pteriatoxins A (20 µg) and B, C (8 µg) were esti1 mated by comparison of the signal-to-noise (S/N) ratio in H NMR spectra of 67 µM okadaic acid with those of pteriatoxins.

Toxicol In Vitro 14:245–251 Douglas DJ, Kenchington ER, Bird CJ, Pocklington R, Bradford B, Silvert W (1997) Accumulation of domoic acid by the sea scallop (Placopecten magellanicus) fed cultured cells of toxic Pseudo-nitzschia multiseries. Can J Fish Aquat Sci 54:907–913 Duda TF, Bingham JP, Livett BG, Kohn AJ, Raybaudi-Massilia G, Schultz JR, Down J, Sandall D, Sweedler JV (2004) How much at risk are cone snails? Science 303:955 Fahey SJ, Garson MJ (2002) Geographic variation of natural products of tropical nudibranch Asteronotus cespitosus.

7. The positive ion ESI MS/MS of 11 and 12 showed the same series of prominent fragment ions as the macrocyclic moiety in pinnatoxins and pteriatoxin A (10). Therefore, pteriatoxins B (11) and C (12) were also assumed to have the same polyether macrocycles as pinnatoxins. The observation of fragmentation ion peaks (m/z 787, 744, 710) suggested the presence of a cysteine moiety in the side-chain. Furthermore, the observation of another fragment ion peak (m/z 712), which was not observed in 10, suggested the presence of a hydroxymethyl group.

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