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By M. Sip, M. Leng (auth.), Prof. Dr. Fritz Eckstein, Prof. Dr. David M. J. Lilley (eds.)

Molecular biology is likely one of the so much quickly turning out to be develo- ping and at thesame time most enjoyable disciplines. the main to molecular biology lies within the realizing of nucleic a- cids - their constitution, functionality, and interplay with seasoned- teins. Nucleic Acids and Molecular Biology retains scientists proficient of the explosively starting to be info and complies with with the good curiosity during this box through supplying a persisted excessive common of assessment. a considerable a part of this quantity has been dedicated to the research of alternative features of nucleic acid-protein-interactions together with RNA- protein-interaction.

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Nature 353:715-719 He Y-Y, McNally T, Manfield I, Navratil 0, Old IG, Phillips SEV, Saint Girons I, Stockley PG (1992) Probing met repressor-operator interactions in solution. Nature 359:431-433 HoI WGJ, van Duijnen PT, Berendsen HJC (1978) The a-helix dipole and the properties of proteins. 8A resolution - a framework for understanding homeodomain-DNA interactions. Cell 63:579-590 Klug A, Jack A, Viswamitra MA, Kennard 0, Shakked Z, Steitz TA (1979) A hypothesis on a specific sequence-dependent conformation of DNA and its relation to the binding of the lac-repressor protein.

The other four structures were determined by molecular replacement using the refined molecular model of the repressor from ApoMetJ I (Rafferty et al. 1989; Somers and Phillips 1992), making the assumption that the overall structure of the repressor is similar in all forms. 1 Structure of the Repressor The fold of the repressor is unlike that of any other known protein structure, with the exception of Arc repressor from bacteriophage P22 (Breg et al. 1990), which is much smaller but closely related.

3 represents the correct alignment of repressors on the operator. In three dimensions the array corresponds to a left-handed superhelix of repressors wound around duplex B-DNA, with a relative rise and rotation between molecules of 8 bp (ca. 27 A) and 2 3 4 5 a Fig. 3. a Schematic representation of an array of met repressors bound to a string of five tandem consensus met boxes. Five repressor dimers (1-5) are shown as JJJrJJJJ, with their dyad axes (A) coincident with local dyads in the centre of each met box (%).

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