Download Signal Transduction and the Gasotransmitters: NO, CO, and by Rui Wang (auth.), Rui Wang MD, PhD, FAHA (eds.) PDF

By Rui Wang (auth.), Rui Wang MD, PhD, FAHA (eds.)

Gasotransmitters-principally nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)-are endogenous signaling molecules that play an important position within the biomedical, medical, and overall healthiness sciences, in addition to in inhabitants well-being stories. In sign Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and medication, a panel of unique researchers and clinicians evaluation the organic and biomedical points of gasotransmitters, emphasizing their signaling transduction mechanisms usually, and ion channel rules particularly. The authors talk about the endogeneous metabolism and law of gasotransmitters, their toxicological profiles and organic activities, and their interactions when it comes to their construction and results. The physiological roles of NO, CO, and H2S within the legislation of the cardiovascular, neuronal, and gastrointestinal platforms, in addition to of telephone metabolism, also are reviewed, in addition to the interplay of the gastrotransmitters with KATP,KCa voltage-gated Ca2+, voltage-gated Na+, and cyclic nucleotide-gated ion channels. integrated within the array of alternative mechanisms for the interplay of NO, CO, and H2S are channel phosphorylation, S-nitrosylation, carboxylation, sulfuration, and adjusted mobile redox prestige. The authors additionally provide tips and recommendations for exploring and additional characterizing different nonetheless unknown gasotransmitters.
Authoritative and accomplished, sign Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and drugs deals scientific scientists and physicians not just a deeper knowing, but in addition a state of the art assessment, of the severely vital box of gasotransmitter biology and medicine.

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Additional resources for Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine

Example text

H 2 S in vivo is metabolized by oxidation in mitochondria or by methylation in cytosol (Fig. 1). H 2 S can be scavenged by methemoglobin (20) or metallo- or disulfide-containing molecules such as oxidized glutathione (21). H 2 S is excreted mainly by the kidney as free or conjugated sulfate (20). The interaction of hemoglobin and H 2 S calls for special attention. Hemoglobin may be the common "sink" for CO in forming scarlet carboxyhemoglobin (22), for NO in forming nitrosyl hemoglobin, and for H 2 S in forming green sulfhemoglobin (23).

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